Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives

Genetic editing technologies have emerged as a potential therapeutic tool in various biomedical fields owing to their applications against cancer, neurological diseases, diabetes, autoimmune disorder, muscular dystrophy, bacterial infections (AMR), and cardiovascular diseases. CRISPR is one such valuable genetic with extensive appliances but major challenge terms of delivery. Herein, we strived exploit synergy nanocarriers the aforementioned diseases for medical explicated clinical significance including enhanced delivery via endosomal escape environmental factors light, pH, stimuli. In addition highlighting strategies nano-carriers characterization, expounded on reliant factor CRISPR-Cas Complex.